Abstract: Aiming at the severe situation faced by the safety management of high laboratories in China, the functional resonance method is used to analyze the typical laboratory explosion accident cases. To reduce the subjectivity in the analysis process, standard operating procedure analysis was introduced to improve the existing FRAM (the Functional Resonance Analysis Method) method, and the large explosion accident of "12·26" in some university was analyzed. First, in-depth analysis of relevant standard documents and laboratory management systems was carried out. Secondly, according to the relevant regulations and the actual situation, the accident system is divided into 10 system functions, including experiment preparation, scientific research project risk assessment, hazardous chemicals purchase, etc., and an ideal functional network diagram was drawn. Finally, combined with the on-site situation, the functional resonance analysis is carried out, and the failure path is removed, and the actual functional network diagram is obtained. The results showed that: the main reason for the accident was that the project leader acted in violation of the regulations, avoided the normal approval process, and carried out experiments in violation of regulations; the project leader had weak safety awareness and did not respond well to the laboratory situation; the safety supervision mechanism of the unit involved did not play a role.

Key words: laboratory explosion accidents, the functional resonance method, accident analysis, system theory